Zanafex vs Flexeril: What to Know About Each

Zanafex vs Flexeril: What to Know About Each

For musculoskeletal problems, such as acute neck or back pain, both cyclobenzaprine and tizanidine were proven to be helpful. It’s crucial that you always inform your healthcare provider about all medications you are taking. Both Zanaflex and Flexeril have potential drug-drug interactions that could result in serious complications. A thorough understanding of your medication history allows for safer prescription practices. Both Zanaflex and Flexeril, like other muscle relaxants, can potentially worsen symptoms in some people. If you observe an increase in dizziness, confusion or abnormal behavior after taking these medications, it’s important to seek immediate medical attention.

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Tizanidine is usually prescribed alongside physical therapy to help ease discomfort during treatment. Drugs like Zanaflex and Flexeril are often recommended along with physical therapy to relieve pain. Consult a healthcare provider to determine the best treatment option for you. Tizanidine works on the central nervous system to stop muscle spasms from occurring. When you have a spinal cord injury or Multiple Sclerosis, you may not have full control over your muscles. Impulses from your brain can cause sudden and sometimes harmful muscle spasms.

What Are Possible Side Effects of Zanaflex?

For people who struggle to swallow, the doctor may have that individual open the capsule and put it in something like applesauce or pudding. Because this impacts absorption it’s important to only do this under the direction of your doctor. You should have regular appointments with your healthcare provider when taking a muscle relaxant to assess how well it’s working. Each type of prescription muscle relaxer has different possible side effects. It’s important to talk to your provider or a pharmacist about possible side effects of the specific medication you’re taking or thinking of taking.

  • Reviewing your symptoms, current medication list, and medical history with your healthcare provider is the best way to decide which muscle relaxer will work best.
  • Tizanidine is an oral drug that is available both in generic and brand name.
  • At We Level Up, various therapeutic techniques are utilized in their treatment approach.
  • Other reported side effects include urinary tract infections (UTIs) and involuntary movements (dyskinesia).
  • Flexeril is a muscle relaxant that can be prescribed as part of a treatment for muscle spasticity that includes physical therapy and rest.
  • Flexeril is generally indicated as an adjunct to rest and physical therapy for relief of muscle spasm while Zanaflex is used to treat conditions such as multiple sclerosis or spinal injury.

According to a meta-analysis, cyclobenzaprine has been studied in the most clinical trials with evidence to support its use. Tizanidine was shown to be effective for spasticity due to multiple sclerosis. Both cyclobenzaprine and tizanidine were found to be effective for musculoskeletal conditions such as acute neck or back pain.


According to, tizanidine treatment usually starts with an initial dose of 2 mg (milligrams) that is taken every six to eight hours three times a day. The dosage may then be increased to 2 to 4 mg every one to four days. People with stiff or tight muscles may be prescribed tizanidine or Flexeril to help ease these mild-to-painful conditions. Spinal injuries and neurological disorders such as cerebral palsy and multiple sclerosis can bring on muscle spasticity, limiting normal muscle movement.

Doctors will usually taper patients off Zanaflex slowly so they don’t go into withdrawal. The recommended dose of cyclobenzaprine dose is 5 or 10 mg three times daily using immediate release tablets or 15 or 30 mg once daily using extended release tablets. If you are pregnant or breastfeeding, you should also discuss using cyclobenzaprine with your healthcare provider. Although not common, in some cases tizanidine and cyclobenzaprine have been misused or abused. Cyclobenzaprine likely treats fibromyalgia by increasing the effects of norepinephrine, a substance in your brain and spinal cord that helps reduce pain signals. They differ by the dosage prescribed and treatment length, and they also have different half-lives, the time it takes for the drug to reduce by one-half, or 50 percent, in the bloodstream.

Comparing Flexeril vs Zanaflex

Always inform your doctor if you are taking any other medicine and of any medical conditions, like liver or kidney disease, before getting prescribed either medication is essential. Addiction Resource does not offer medical diagnosis, treatment, or advice. Only trained and licensed medical professionals can provide such services. If you or anyone you know is undergoing a severe health crisis, call a doctor or 911 immediately.

These medications can further increase the side effects of tizanidine. Both tizanidine and cyclobenzaprine can cause problems if you take them when you have certain other health issues. You should avoid using cyclobenzaprine if you have a slow heart rhythm or heart rhythm problems.

In some cases, doctors may prescribe Tizanidine for other ailments and purposes. There is some evidence that off-label use of Tizanidine is effective to treat other conditions. Tizanidine may be prescribed for insomnia, migraine headaches, and even back pain.

Talk to your provider if you experience any bothersome side effects. From 2004 to 2015, cyclobenzaprine-related emergency department visits increased by 79.1%. Make your tax-deductible gift and be a part of the cutting-edge research and care that’s changing medicine. Prices for Zanaflex (tizanidine) start under $5 for a bottle of 30 tablets, strength 4 mg. To find the least expensive pharmacy near you, and to obtain a coupon, visit the GoodRX generic Zanaflex page. Prices for Robaxin (methocarbamol) start around $8 for a bottle of 60 tablets, strength 500 mg.